PRC Pathway Modulator Set

Description

A convenient set containing 6 ready-to-use Polycomb inhibitors and activators. The set comprises high-purity compounds carefully chosen for their selectivity and potency, providing the perfect tool to study Polycomb-group proteins function and PcG related pathways. All compounds are provided in screw-cap vials, already dissolved in DMSO at a 10 mM concentration. Compounds in DMSO solution may precipitate out of solution when stored at reduced temperatures. Before use, make sure all vials have warmed to room temperature. Please examine all vials to ensure that all material has redissolved slight warming and/or sonication may be required. The set contains: DZNep - Selective lysine methyltransferase EZH2 KMT63 inhibitor EED-226 - Potent, selective PRC2 inhibitor PRT4165 - Potent inhibitor of PRC1 - mediated histone H2A ubiquitylation PTC209 - BMI-1 inhibitor Tazemetostat - Potent, selective histone methyltransferase EZH2 inhibitor UNC3866 - Potent, selective antagonist of CBX4 and CBX7 chromodomains