GENERAL CATALOGUE
Prexasertib
HY-18174 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-18174
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Catalog No: HY-18174
CAS No: 1234015-52-1
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Prexasertib LY2606368 is a selective, ATP-competitive second-generation checkpoint kinase 1 CHK1 inhibitor with a Ki of 0.9 nM and an IC50 of 1 nM. Prexasertib inhibits CHK2 IC50=8 nM and RSK1 IC50=9 nM . Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity.
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