GENERAL CATALOGUE
PRMT5-MTA-IN-4
HY-176701 · 50 mg
MedChemExpress · Cat: HY-176701
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Catalog No: HY-176701
CAS No: 3025838-18-7
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
PRMT5-MTA-IN-4 Compound 30 is a potent irreversible protein arginine methyltransferase 5 PRMT5 inhibitor IC50=8 nM . PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines e.g., IC50=0.3 ?M in DLD-1 cells . PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma.