PRMT7-IN-2

Description

PRMT7-IN-2 A33 is a selective PRMT7 inhibitor with an IC50 of 0.50 ?M. PRMT7-IN-2 arrests cell cycle at G0/G1 phase, induces cell apoptosis, and inhibits cell growth in vivo and in vitro. PRMT7-IN-2 decreases the monomethylarginine level of PRMT7, increases expression of epithelial marker E-cadherin, and reduces expression of mesenchymal markers such as N-cadherin, Vimentin, and ZEB2.