pro-FTY

Description

pro-FTY, a FTY720 HY-12005 anticancer prodrug, is a sphingosine-1-phosphate S1P HY-108496 inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system DDS that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel HY-B0015 or Doxorubicin HY-15142A . pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia.