Proadifen hydrochloride

Description

Proadifen SKF-525A hydrochloride is a non-competitive Cytochrome P450 inhibitor with an IC50 value of 19 ?M. Proadifen hydrochloride reduces monoamine oxidase A MAO-A activity and reverses the antidepressantlike behavioral effect of Imipramine HY-B1490A and Desipramine HY-B1272A in rats. Proadifen hydrochloride also reduces N, N-dimethyltryptamine DMT metabolism in liver microsomes and inhibits N-demethylationand Acridone HY-W007771 formation. Proadifen hydrochloride augments Lipopolysaccharide LPS HY-D1056 -induced fever and exacerbates Prostaglandin E2 PGE2 HY-101952 levels in the rat. Proadifen hydrochloride is promising for research of metabolism-related deseases, ovarian carcinoma, inflammation and dopamine neurons-related deseases.