GENERAL CATALOGUE
Prostaglandin J2
HY-113366 · 500 g
MedChemExpress · Cat: HY-113366
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medchemexpress.com/prostaglandin-j2.htmlCatalog No: HY-113366
CAS No: 60203-57-8
Category: GPCR G Protein
Pack Size: 500 g
Brand: MedChemExpress
Description
Prostaglandin J2 PGJ2 , an endogenous metabolite of Prostaglandin D2 PGD2; HY-101988 , is a potent PGD2 receptor DP agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated Ub proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimers AD and Parkinsons diseases PD .
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