PROTAC 20S proteasome subunit ?5 degrader 1

Description

PROTAC 20S proteasome subunit ?5 degrader 1 compound 12f is a targeted degrader of PROTAC for 20S proteasome subunit ?5, with a DC50 value of 0.11 ?M in FaDu cells. PROTAC 20S proteasome subunit ?5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit ?5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib HY-10227 Pink: Target protein ligand HY-10227 ; Blue: E3 ligase ligand HY-103596 ; Black: Linker HY-169142 .