GENERAL CATALOGUE
PROTAC AR Degrader-8
HY-170329 · 1 mg
MedChemExpress · Cat: HY-170329
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medchemexpress.com/protac-ar-degrader-8.htmlCatalog No: HY-170329
CAS No: 3044108-04-2
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
PROTAC AR Degrader-8 Compound NP18 is the PROTAC degrader for androgen receptor AR , that degrades AR-FL with DC50 of 0.018 ?M and 0.14 ?M in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC50 of 0.026 ?M in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC50 of 0.038 ?M and 1.11 ?M. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model. Pink: ligand for target protein AR ligand-33 HY-170330 ; Black: linker HY-W007731 ; Blue: ligand for E3 ligase Cereblon HY-14658