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PROTAC AR-NTD degrader 1
GENERAL CATALOGUE

PROTAC AR-NTD degrader 1

HY-149434 · 50 mg

MedChemExpress · Cat: HY-149434

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Catalog No: HY-149434
CAS No: 3032601-92-3
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

PROTAC AR-NTD antagonist 1 compound 18 is a small molecule protein-targeting chimera PROTACs targeting the Androgen Receptor AR-V7. PROTAC AR-NTD antagonist 1 antagonizes the N-terminal domain of AR AR-NTD , degrades AR-V7 protein, and induces apoptosis in prostate cancer PC cells. The efficiencies of PROTAC AR-NTD antagonist 1 in degrading AR-V7 in VCaP cells were 62.2 % 1 ?M and 71.1 % 5 ?M , respectively.

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