PROTAC Bcl-xL degrader-4

Description

PROTAC Bcl-xL degrader-4 Compound 2-38-III is a Bcl-xL PROTAC degrader. PROTAC Bcl-xL degrader-4 has strong anti-tumor activity against HepG2 cells and HUVEC cells. PROTAC Bcl-xL degrader-4 induces cells apoptosis by decreasing mitochondrial membrane potential and activating the MAPK signaling pathway. PROTAC Bcl-xL degrader-4 significantly inhibits tumor growth in xenograft tumor mouse models. Pink: MAPK ligand HY-176741 ; Blue: CRBN ligase ligand HY-10984 ; Black: linker HY-W017440