GENERAL CATALOGUE
PROTAC Bcl2 degrader-1
HY-125876 · 1 mg
MedChemExpress · Cat: HY-125876
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medchemexpress.com/bcl2-in-1.htmlCatalog No: HY-125876
CAS No: 2378801-85-3
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
PROTAC Bcl2 degrader-1 Compound C5 is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 IC50, 4.94 ?M; DC50, 3.0 ?M and Mcl-1 IC50, 11.81 ?M by introducing the E3 ligase cereblon CRBN -binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 Blue: CRBN ligand, Black: linker?Pink: Mcl-1/Bcl-2 inhibitor, Nap-1 .
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