

HY-130612 · 50 mg
MedChemExpress · Cat: HY-130612
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medchemexpress.com/protac-brd2-brd4-degrader-1.htmlDescription
PROTAC BRD2/BRD4 degrader-1 compound 15 is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2/BRD4 degrader-1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon CRBN /cullin 4A.

