PROTAC CARM1/IKZF3 degrader-1

Description

PROTAC CARM1/IKZF3 degrader-1 Compound 074 inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs IMiD, such as pomalidomide resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research. Pink: ligand for target protein CARM1/IKZF3 ligand 1 HY-172369 ; Active form of target protein ligand: EZM 2302 HY-111109 ; Black: linker HY-21999 ; Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride HY-41547