GENERAL CATALOGUE
PROTAC CDK9 degrader-11
HY-170978 · 50 mg
MedChemExpress · Cat: HY-170978
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Manufacturer product page
medchemexpress.com/protac-cdk9-degrader-11.htmlCatalog No: HY-170978
CAS No: 3039540-19-4
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC CDK9 degrader-11 Compound C3 is an orally active PROTAC degrader for CDK9 with DC50 of 1.09 nM. PROTAC CDK9 degrader-11 exhibits cytotoxicity in multi small cell lung cancer cell with IC50 of nanomolar levels. PROTAC CDK9 degrader-11 arrests cell cycle at G0/G1 phase, inhibits the cell invasion in DMS114 and DMS53 cell. PROTAC CDK9 degrader-11 exhibits antitumor efficacy in NCI-H446 xenograft mouse models. Pink: ligand for target protein CDK9 ligand 3 HY-170979 ; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56 HY-W247437
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