GENERAL CATALOGUE
PROTAC EGFR degrader 4
HY-146349 · 1 mg
MedChemExpress · Cat: HY-146349
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medchemexpress.com/protac-egfr-degrader-4.htmlCatalog No: HY-146349
CAS No: 2882845-50-1
Category: Autophagy
Pack Size: 1 mg
Brand: MedChemExpress
Description
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy.
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