

HY-161536 · 5 mg
MedChemExpress · Cat: HY-161536
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medchemexpress.com/protac-egfr-degrader-9.htmlDescription
PROTAC EGFR degrader 9 Compound C6 is an orally active CRBN-based PROTAC EGFR degrader. PROTAC EGFR degrader 9 exhibits a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTAC EGFR degrader 9 exhibits potent degradation activity against various EGFR mutants, while sparing the EGFRWT. Blue: CRBN ligand HY-A0003 , Black: linker HY-161613 ; Pink: EGFR inhibitor HY-161537 .







