PROTAC EML4-ALK Degrader-1

Description

PROTAC EML4-ALK Degrader-2 Pro-BA is a selective and orally active linker-free EML4-ALK PROTAC degrader with the DC50 of 74 nM in H1322 cells T1/2 = 8 h . PROTAC EML4-ALK Degrader-2 relies on GID4 and proteasome pathways to promote ubiquitination of target proteins, leading to cell apoptosis. PROTAC EML4-ALK Degrader-2 can be used for research on cancer. Pink: EML4-ALK Ligand HY-40114 ; Blue: GID4 Ligand HY-150908