PROTAC ER? Degrader-11

Description

PROTAC ER? Degrader-11 is a selective and intrinsically fluorescent Ex: 366 nm, Em: 440 nm ER? PROTAC degrader. PROTAC ER? Degrader-11 shows good antiproliferative activity, selective ER? degradation and imaging capabilities in MCF-7 breast cancer cell lines. PROTAC ER? Degrader-11 induces G2/M phase arrest and induces apoptosis in MCF-7 cells. PROTAC ER? Degrader-11 is well-tolerated up to a dose of 500 mg/ kg with no acute toxicity in athymic nude mice. PROTAC ER? Degrader-11 can be used for the study of breast cancer. Pink: ER? ligand HY-167701 , Blue: CRBN Ligand HY-150831 , Black: Linker, E3 ligase ligand-linker conjugate HY-174880 .