PROTAC ER? Degrader-12

Description

PROTAC ER? Degrader-12 is a potent and selective Er? PROTAC degrader. PROTAC ER? Degrader-12 has antiproliferative effects in multiple breast cancer cell lines with wild-type or mutant ER?. PROTAC ER? Degrader-12 can halt the cell cycle and induce cell apoptosis. PROTAC ER? Degrader-12 exhibits excellent antitumor and ER? degradation activity. PROTAC ER? Degrader-12 can be used for research on breast cancer. Pink: ER ligand-11 HY-174475 ; Blue: VHL ligand HY-112078 ; Black: Linker HY-W088749 ; VHL ligand + Linker HY-W998310 .