GENERAL CATALOGUE
PROTAC FLT3/CDKs degrader-1
HY-161708 · 50 mg
MedChemExpress · Cat: HY-161708
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medchemexpress.com/protac-flt3-cdks-degrader-1.html
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Catalog No: HY-161708
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC FLT3/CDKs degrader-1 Compound C3 is a degrader for cyclin-dependent kinases DC50 is 18.73 nM for CDK2 and the FMS-like tyrosine kinase 3 FLT3 . PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 72.77 % differentation at 6.25 nM , inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. Pink: ligand for target protein FLT3/CDKs ligand-1 HY-161709 ; Black: linker HY-W012935 ; Black: ligand for E3 ligase Thalidomide 5-fluoride HY-W087383
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