GENERAL CATALOGUE
PROTAC GPX4 degrader-4
HY-174086 · 50 mg
MedChemExpress · Cat: HY-174086
Reach 3+ verified distributors
Manufacturer product page
medchemexpress.com/protac-gpx4-degrader-4.html
Sponsored
Catalog No: HY-174086
CAS No: 3071165-43-7
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC GPX4 degrader-4 is a GPX4 PROTAC degrader DC50: 5.32 nM . PROTAC GPX4 degrader-4 inhibits the activity of RT4, T24, and J82 cancer cells IC50 values are 0.09, 2.97, and 7.58 ?M, respectively . PROTAC GPX4 degrader-4 increases lipid ROS levels and induces ferroptosis in T24 and RT4 cells. PROTAC GPX4 degrader-4 has antitumor activity in T24 tumor-bearing BALB/c nude mouse model. PROTAC GPX4 degrader-4 can be used for bladder cancer research. Pink: target protein ligand HY-N0193 ; blue: E3 ligase ligand HY-1035960 ; black: linker HY-W013907 ; E3 ligase ligand + linker HY-174087 .