GENERAL CATALOGUE
PROTAC HER2 degrader-1
HY-177008 · 1 mg
MedChemExpress · Cat: HY-177008
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Manufacturer product page
medchemexpress.com/protac-her2-degrader-1.htmlCatalog No: HY-177008
CAS No: 2897640-93-4
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
PROTAC HER2 degrader-1 is a highly selective HER2 PROTAC degrader, with a DC50 of 69 nM and a Dmax of 96 %. PROTAC HER2 degrader-1 inhibits HER2-positive cell proliferation and tumor growth through persistent HER2 degradation and potent inhibition of downstream pathways AKT and ERK . PROTAC HER2 degrader-1 induces apoptosis in BT-474 cells. PROTAC HER2 degrader-1 can be used for research of HER2-positive cancers. Pink: HER2 ligand: HY-177009 ; Black: Linker; Blue: CRBN ligand: HY-W023573 .
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