PROTAC HK2 Degrader-1

Description

PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine HY-B0486 as a target protein Hexokinase 2 HK2 inhibitor and Thalidomide HY-14658 as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 HK2 protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research.