GENERAL CATALOGUE
PROTAC IRAK4 degrader-13
HY-175022 · 50 mg
MedChemExpress · Cat: HY-175022
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Manufacturer product page
medchemexpress.com/protac-irak4-degrader-13.htmlCatalog No: HY-175022
CAS No: 2432992-21-5
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC IRAK4 degrader-13 Degrader 1 is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod HY-B0180 induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa HS and atopic dermatitis AD research. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker
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