GENERAL CATALOGUE
PROTAC KDM3 degrader-1
HY-168593 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-168593
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Manufacturer product page
medchemexpress.com/wnt-%CE%B2-catenin-in-5.htmlCatalog No: HY-168593
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
PROTAC KDM3 degrader-1 Compound 4 is a CRBN-recruiting PROTAC designed based on the IOX1 HY-12304 scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/?-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer Target protein ligand Pink : HY-12304; linker Black : HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase Blue : HY-41547 .
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