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PROTAC KDM4 degrader-1
GENERAL CATALOGUE

PROTAC KDM4 degrader-1

HY-173135 · 50 mg

MedChemExpress · Cat: HY-173135

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Catalog No: HY-173135
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

PROTAC KDM4 degrader-1 Compound 11 is a KDM4-targeted proteolysis targeting chimeras PROTAC degrader. PROTAC KDM4 degrader-1 can degrade KDM4A-C while sparing KDM4D. PROTAC KDM4 degrader-1 exhibits potent antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 induces apoptosis and cell cycle arrest, and inhibits histone H3 lysine demethylation. Blue: E3 ligase ligand HY-112078 , Black: linker HY-W013381 ; Pink: ligand for target protein HY-173136 .

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