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PROTAC KRAS G12D degrader 1
GENERAL CATALOGUE

PROTAC KRAS G12D degrader 1

HY-161176 · 1 mg

MedChemExpress · Cat: HY-161176

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Catalog No: HY-161176
CAS No: 3033583-54-6
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress

Description

PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader. PROTAC KRAS G12D degrader 1 inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. PROTAC KRAS G12D degrader 1 inhibits tumor growth in mice bearing AsPC-1 xenografts. PROTAC KRAS G12D degrader 1 can be used for the study of KRASG12D-driven cancers. Pink: KRAS ligand HY-175892 , Blue: VHL Ligand HY-112078 , Black: Linker, E3 ligase ligand-linker conjugate HY-175893 .

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