PROTAC KSP-IN-1

Description

PROTAC KSP-IN-1 Compound 21 is a PROTAC Degrader for kinesin spindle protein KSP , that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP-IN-1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP-IN-1 exhibits antitumor efficacy in mouse model. Blue: Ligand for E3 Ligase Cereblon HY-103596 ; Blank: Linker HY-168726 ; Pink: Target Protein Ligand HY-168727