PROTAC LZK degrader 1

Description

PROTAC LZK degrader 1 Compound 21A is a PROTAC that targets the degradation of LZK Leucine Zipper Kinase, encoded by MAP3K13 . PROTAC LZK degrader 1 10 ?M promotes the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma HNSCC cell lines. PROTAC LZK degrader 1 can be used in cancer research. PROTAC LZK degrader 1 consists of an E3 ligase ligand blue part, HY-112078 , a target protein ligand red part, HY-170596 , and a linker black part, HY-W019543 1 .