GENERAL CATALOGUE
PROTAC PDE4 degrader-1
HY-174405 · 50 mg
MedChemExpress · Cat: HY-174405
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Manufacturer product page
medchemexpress.com/protac-pde4-degrader-1.htmlCatalog No: HY-174405
CAS No: 3087311-36-9
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC PDE4 degrader-1 Compound 9m is a selective and orally active PDE4 PROTAC degrader with a DC50 of 41.98 ?M. PROTAC PDE4 degrader-1 potently inhibits the secretion of pro-inflammatory cytokines such as TNF-? and IL-6. PROTAC PDE4 degrader-1 significantly alleviates pulmonary inflammation in LPS HY-D1056 -induced acute lung injury ALI mice Model. Pink: PDE4 ligand HY-174410 ; Blue: CRBN ligase ligand HY-10984 ; Black: linker
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