PROTAC PI3K? degrader-1

Name: PROTAC PI3K? degrader-1
Brand: MedChemExpress

HY-176239 · 50 mg

MedChemExpress · Cat: HY-176239

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medchemexpress.com/protac-pi3k%CE%B4-degrader-1.html

Catalog No: HY-176239

Category: Apoptosis

Pack Size: 50 mg

Brand: MedChemExpress

Description

PROTAC PI3K? degrader-1 is a Lysine-targeted covalent PI3K? PROTAC degrader with a DC50 of 3.98 nM. PROTAC PI3K? degrader-1 has a potent antiproliferative activity and selective PI3K? inhibition IC50: 8 nM . PROTAC PI3K? degrader-1 also significantly degrades p-AKT, induces cell cycle arrest in G1 phase and prompts cell apoptosis and autophagy. PROTAC PI3K? degrader-1 effectively inhibits the tumor growth in SU-DHL-6 xenograft mice model. Pink: PI3K? ligand HY-169983 ; Blue: VHL ligase ligand HY-112078 ; Black: linker HY-W013381