GENERAL CATALOGUE
PROTAC SARS-CoV-2 Mpro degrader-3
HY-161789 · 50 mg
MedChemExpress · Cat: HY-161789
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medchemexpress.com/protac-sars-cov-2-mpro-degrader-3.htmlCatalog No: HY-161789
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC SARS-CoV-2 Mpro degrader-3 Compound P2 exhibits antiviral activity through the degradation of the main protease Mpro of human coronaviruses HCoVs DC50=27 ?M . PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC50 of 4.6 ?M, 4.6 ?M, and 0.71 ?M, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. Pink: ligand for target protein Mpro ligand 2 HY-161791 ; Black: linker HY-161792 ; Blue: ligand for E3 ligase S,R,S -AHPC HY-125845 .