GENERAL CATALOGUE
PROTAC SOS1 degrader-10
HY-161654 · 50 mg
MedChemExpress · Cat: HY-161654
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Manufacturer product page
medchemexpress.com/protac-sos1-degrader-10.htmlCatalog No: HY-161654
CAS No: 3043923-74-3
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC SOS1 degrader-10 Compound 11o is a degrader for son of sevenless 1 SOS1 in a CRBN and proteasome dependent manner. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS mutant cancer cells SW620, A549 and DLD-1, with DC50s of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits the proliferations of cells SW620, A549 and DLD-1, with IC50s of 36.7, 52.2 and 107 nM, respectively. PROTAC SOS1 degrader-10 inhibits phosphorylation of ERK. Pink: SOS1 ligand HY-161655 ; Black: linker HY-161656 ; Blue: E3 ligase ligand HY-W249500
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