GENERAL CATALOGUE
PROTAC STING degrader-4
HY-176180 · 50 mg
MedChemExpress · Cat: HY-176180
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Catalog No: HY-176180
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
PROTAC STING degrader-4 is a nitro-free covalent STING PROTAC degrader with a DC50 of 3.23 ?M. PROTAC STING degrader-4 effectively inhibits STING as well as its downstream signaling, such as p-TBK1 and p-NF-?B p-P65 , and immune-inflammatory cytokines. PROTAC STING degrader-4 mitigates kidney and blood inflammation in Cisplatin HY-17394 -induced acute kidney injury AKI mice model. Pink: STING ligand HY-176183 ; Blue: CRBN ligase ligand HY-103596 ; Black: linker HY-176182 ; CRBN ligase ligand + linker: HY-176181
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