GENERAL CATALOGUE
PRT3789
HY-159607 · 1 mg
MedChemExpress · Cat: HY-159607
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medchemexpress.com/smarca2-degrader-17.html
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Catalog No: HY-159607
CAS No: 2755761-78-3
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
PRT3789 is a SMARCA2 PROTAC degrader DC50 in HeLa cell: 0.72 nM for SMARCA2, 14 nM for SMARCA4 . PRT3789 shows synergistic anti-proliferation effects with Adagrasib HY-130149 in cancer cells. PRT3789 inhibits SMARCA4-mutated lung cancer proliferation. PRT3789 inhibits tumor growth in SMARCA4-deleted NSCLC models. Pink: SMARCA4 ligand HY-44824 ; Blue: VHL ligand HY-159465 ; Black: linker; VHL ligand+linker HY-172738 .
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