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PRX-08066
GENERAL CATALOGUE

PRX-08066

HY-15472 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-15472

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Manufacturer product page

medchemexpress.com/PRX-08066.html
Catalog No: HY-15472
CAS No: 866206-54-4
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

PRX-08066 is a selective and orally active 5-hydroxytryptamine receptor 2B 5-HT2BR antagonist with a Ki of 3.4 nM. PRX-08066 inhibits the MAPK pathway, 5-HT release and fibrotic factor TGF?1, CTGF and FGF2 expression. PRX-08066 inhibits the proliferation of KRJ-I cells and induces apoptosis caspase-3 activation . PRX-08066 inhibits pulmonary vascular remodeling. PRX-08066 can be used of pulmonary Arterial Hypertension PAH and neuroendocrine tumor NET .

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