PSMA Fc Chimera, Human

Description

Prostate-specific membrane antigen PSMA also known as Folate hydrolase 1 FOLH1 , Folylpoly-gamma-glutamate carboxypeptidase FGCP , Glutamate carboxypeptidase 2 GCP2 , N-acetylated-alpha-linked acidic dipeptidase I NAALAD1 , is a type II membrane glycoprotein that is expressed in prostate tissue and to a lesser extent in the peripheral and central nervous system, small intestinal, and salivary gland tissues. PSMA has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase NAALADase activity and has a preference for tri-alpha-glutamate peptides. The catalytic activity of PSMA involves the release of unsubstituted C-terminal glutamyl residues, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. PSMA is used as a diagnostic and prognostic indicator of prostate cancer, and as a possible marker for various neurological disorders such as schizophrenia, Alzheimers disease, and Huntingtons disease.