

HY-167832 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-167832
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medchemexpress.com/pt109.htmlDescription
PT109 is a multi-kinase inhibitor. PT109 inhibits JNK JNK1: IC50=0.143 ?M; JNK2: IC50=0.831 ?M; JNK3: IC50=0.285 ?M and other kinases SGK1: IC50=1.34 ?M; SGK2: IC50=5.6 ?M; SGK3: IC50=26.4 ?M; ROCK2: IC50=34 ?M and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme GBM into oligodendrocytes through the PTBP1/PKM1/2 pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity.





