GENERAL CATALOGUE
PTP1B/AKR1B1-IN-1
HY-149254 · 50 mg
MedChemExpress · Cat: HY-149254
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medchemexpress.com/ptp1b-akr1b1-in-1.htmlCatalog No: HY-149254
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B PTP1B and aldose reductase AKR1B1 , with IC50s of 0.06 ?M and 4.3 ?M, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC50 value of 9 ?M. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus T2DM to control blood glucose levels.
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