PUMA Rabbit Monoclonal Antibody

Description

EnkiLife offers the PUMA Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat, species and is suitable for WB,IHC,ICC/IF,ELISA,IP application. Alternative Names of Immunogen: BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-reguLated moduLator of apoptosis. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:2000-1:10000,IHC 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 Background: Cell localization:Mitochondrion.This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],