GENERAL CATALOGUE
Purinostat
HY-150109A · 5 mg
MedChemExpress · Cat: HY-150109A
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medchemexpress.com/purinostat.htmlCatalog No: HY-150109A
CAS No: 1929583-17-4
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate HY-150109 , the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell LSC survival, including c-Myc, ?-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1.