

HY-164523 · 50 mg
MedChemExpress · Cat: HY-164523
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medchemexpress.com/pv1162.htmlDescription
PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site adenine-binding region , thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy.





