GENERAL CATALOGUE
PVTX-405
HY-172930 · 5 mg
MedChemExpress · Cat: HY-172930
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Catalog No: HY-172930
CAS No: 2991021-08-8
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC50? of ?0.7?nM and a Dmax of 91 %. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC50 of 48?AAasAasAAmuM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies ICTs anti-PD1 or anti-LAG3 in the MC38 mouse tumor xenograft model using Crbn391V C57BL/6 mice.
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