PXL770

Description

PXL770 is an orally active, direct allosteric AMP-activated protein kinase AMPK activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters ABCD2/3 in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet HFD -fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy ALD , autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis NASH .