PZ671

Description

PZ671 is a potent Bcl-xL PROTAC degrader with an IC50 of 1.3 nM MOLT-4 cells and a DC50 of 0.9 nM Bcl-xL . PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer SCLC . Structure Note: Pink: Bcl-xL ligand HY-174878 ; Blue: CRBN Ligand HY-138793 ; Black: linker; E3-linker HY-174879