GENERAL CATALOGUE
PZL-A
HY-174216 · 1 mg
MedChemExpress · Cat: HY-174216
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medchemexpress.com/pzl-a.htmlCatalog No: HY-174216
CAS No: 3068830-89-4
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
PZL-A is a activator of mitochondrial DNA mtDNA synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase ? POL? with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA.
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