(R)-(+)-Mequitazine

Description

R - + -Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes, resulting in hydroxylated and S-oxidized metabolites. R - + -Mequitazine competitively binds to the H1 receptors in gastrointestinal, vascular, and respiratory effect cells, thus blocking the endogenous activity of histamine. R - + -Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1AAasAasAa-hydroxylase. R - + -Mequitazine can be used in the study of various allergic diseases.