GENERAL CATALOGUE
(R)-MRT199665
HY-120877A · 1 mg
MedChemExpress · Cat: HY-120877A
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Manufacturer product page
medchemexpress.com/r-mrt199665.htmlCatalog No: HY-120877A
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
R -MRT199665 is an isomer of MRT199665 HY-120877 . MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPK?1/AMPK?2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias AML cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370.
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