(R,R)-MK 287

Description

R,R -MK 287 L-680574 is a tetrahydrofuran derivative that potently inhibits the binding of 3H C18-PAF to human platelets, polymorphonuclear leukocytes PMNs , and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. R,R -MK 287 potently and selectively inhibits PAF-induced platelet aggregation ED50=56 nM and elastase release from PMNs ED50=4.4 nM . R,R -MK 287 inhibits PAF-induced lethality in mice ED50=0.8 mg/kg, po and PAF-induced bronchospasm in guinea pigs ED50=0.18 mg/kg .